Any preferences which can be set within Geneious Prime can also be set from the geneious.properties file which can be found in the Geneious Prime installation directory. On MacOS this file is located in Geneious Prime.app/Contents/Resources/app (Prime 2021.1 and later) or Geneious.app/Contents/Java (Prime 2021.0 and earlier).
Note that on MacOS this file should be copied to an external location before it is edited. Modifying this file directly in the application bundle will break its app signature, which may have unintended side effects such as intermittent application crashes. The file should be copied to either
/Users/(username)/Library/Application Support/Geneious/geneious.properties (to set properties for a single user account)
or
/Library/Application Support/Geneious/geneious.properties (to set properties for all users of a computer)
Properties defined for all users take priority over properties defined for individual users.
Some examples of how to modify geneious.properties are present in the file already - remove the hashes from the start of the lines and modify the values to use them. If you need to find out how to set other preferences using this file, please contact Geneious support.
It is also possible to turn off access to all external services by editing this file (this is not possible via the preferences inside Geneious). This includes access to NCBI, Uniprot, Geneious plugin download, submission of error reports, support requests and usage tracking.